House treats a 16-year-old chess prodigy who gets everyone on the team annoyed with his behavior. Foreman is upset with House because he thinks his boss sabotaged his job interview with another hospital.

Fry downloads Lucy Liu's image from nappster.com onto a blank robot and falls in love with the computerized image that is programmed to love him back. His friends, who are worried about Fry, try to shut down nappster.com, and discover that the company has actually kidnapped real celebrities. They grab Lucy Liu's preserved head and try to escape, but nappster.com send an army of warrior Lucy Liu-bots after them.

Opting to forgo a picturesque fall wedding to elope in Las Vegas, Karen hops on a plane to "Sin City" with fiancé Lyle and faithful friends Will and Jack – but when she bumps into vacationing superstar Jennifer Lopez, she asks J-Lo to sing at the ceremony. Meanwhile, Leo returns from Cambodia to meet up with Grace at the wedding, but their reunion is delayed by a freak design accident.

As the missile speeds toward its destination, Mandy cuts a deal with Jack and the President to give up Marwan's location in exchange for a full pardon on all of her crimes. Tony and Michelle share a happy reunion, but Jack finds his relationship with Audrey shattered as she makes her feelings known. Logan's advisor suggests a drastic course of action when the Chinese government demands that Jack be handed over to them for trial. Palmer tries desperately to warn Jack of the danger against him. Jack's life changes forever as Tony, Michelle and Chloe help him to evade the ...

Shawn investigates the disappearance of a mummy from the National History Museum.