Tom and Diana continue their investigation on Jordan Collier's plan for mankind. Dennis Ryland returns to NTAC. Isabelle is seriously injured when she takes a classroom hostage.

A murder in a small town is investigated and soon turns out to be an act of vengeance.

Kirsten hits rock bottom after Caleb's funeral, prompting Sandy to finally take action; Jimmy Cooper resurfaces and almost immediately renews ties with a mourning Julie; Jess bullies Trey into participating in a drug deal that turns into a shootout; Ryan finally learns the truth about what happened between Trey and Marissa, leading to a bloody confrontation.

Rory, in her pajamas, meets CNN journalist and her idol Christiane Amanpour. Although Lorelai and Rory have planned a crazy roller coaster tour for the summer, Rory must postpone their trip when she gets a surprise job offer to cover Barack Obama’s presidential campaign for an online magazine in Eldridge, Iowa. She must leave in three days for possibly two years, breaking the hearts of all the townspeople looking forward to her graduation re-enactment in a week. Luke enlists the help of everyone in Stars Hollow to throw Rory a surprise bon voyage party. Also, Lorelai is staying maniacally busy ...

Monica's Porsche shows up again, and becomes a conflict when Rachel finds out she is the only one who hasn't driven it. Meanwhile, Chandler and Monica go off to Vegas to find Chandler's dad and invite him (or her) to the wedding. Back at home, Joey proves his masculinity to Phoebe, while Ross and Rachel hit the freeway in the "bad boy."

Discovering that NTAC is behind the disease plaguing the 4400s, Tom and Diana try to get to the bottom of NTAC's cover-up, while Kyle considers turning himself in.