Dexter has hard times distancing himself from Miguel, after all he's still Dexter's Best Man. Rita has her own dilemma now that she knows Miguel's been seeing another woman.

Monica struggles to decide between Richard and Chandler. Meanwhile, Rachel and Phoebe discuss their backup plans if they are not married before the time they're 40.

Karen and the gang sets sail on her yacht to scatter Stanley's ashes in the Caribbean while Leo is flying to Guatamala with an attractive co-worker. It's discovered that Lorraine has been stowing on board, which leads to a big fight with Karen. Will and Jack get drunk and pass-out together. The next morning Grace finds Leo's bag with a suggestive letter from his co-worker Danni.

Death grants Peter's wish to go back in time to 1984 when he was 18, but only for one night. He ends up bailing on a date with Lois to hang out with a movie actress. When he returns to the present, he soon realizes that everything is anything but normal, as he is now married to the former actress, and Lois is with Quagmire. Meanwhile, Stewie, Chris and Meg have also taken on Quagmire's charming characteristics.

To Monica's horror, Pete plans to be in an ultimate fight, and when he can't win but won't give up, she must decide her future with him. Chandler has a problem when his new boss is slaphappy. Phoebe sets Ross up on a date with a woman who used to be bald.

A human is killed by a vampire in the heat of passion, causing Mick and Beth to face the ultimate consequences of a vampire-human relationship. The investigation of the murder puts Mick and Josef's secret identities in jeopardy, forcing them to join forces with the other vampires in Los Angeles to keep their secret safe.