Cardinal Wolsey attempts to save his career by finding a new, yet surprising ally: Queen Katherine, who has also lost the King's favour. However, their plotting is discovered by the King's advisors.

The team searches for a serial killer who justifies his crimes with paranoid religious motivation set on by a rapidly deteriorating medical condition.

Dexter has hard times distancing himself from Miguel, after all he's still Dexter's Best Man. Rita has her own dilemma now that she knows Miguel's been seeing another woman.

This is the second hour of a 2-hour season finale. A two episode entries have been created. The 10pm EST marker will mark to beginning of the second episode. A couple undergoes surgery. Derek and Meredith clinical trial has another patient. Izzie helps Alex. McSteamy hooks up with someone.

Marshall takes Robin to a bar with a Minnesota theme. Ted attempts to keep his visiting sister away from Barney.