Sam, Dean, and Bobby hunt down Lilith and fight her and her demons in a final effort to save Dean's life.

Sam, Dean, and Ruby look for Anna who hears the voices of angels. When Ruby seemingly betrays the brothers and leaves with Anna, Sam enlightens Dean on how Ruby saved Sam's life while Dean was in Hell.

As the CSI's continue their search for and discover the identity of the "Miniature Killer", Grissom and Sara's relationship gets exposed to the rest of the team as she goes missing during the investigation. The "Miniature Killer" is finally captured, but not before a member of CSI becomes the killer's final victim.

A pregnancy scare has Charlie heading to the doctor for a vasectomy.

First aired: 5/19/2008 Production Code: 3T6616 Penny's break-up spurs Leonard to summon the courage to ask her out, and each goes to Sheldon for advice on their upcoming date.

Fry, in an effort to win Leela's love, makes a deal with the Robot Devil to become a gifted musician. He has tried to take holophonor lessons, but his teacher claimed he had "stupid fingers." Bender realizes that the Robot Devil is the only one to help. Fry makes a deal only to regret it immediately as it comes with a hefty price.