The investigation into the rape and impregnation of a young girl with Down's Syndrome uncovers a serial rapist who preys on handicapped young girls under the guise of being their benefactor.

As Gabrielle prepares for her fairy tale wedding, Bree returns to Fairview with a surprise. Meanwhile, Lynette's mother Stella (guest star Polly Bergen) pays her a visit after finding out Lynette has cancer. Finally, Susan and Mike tie the knot in an unexpected location.

Vince has yet to ink a contract for Aquaman, but that doesn’t stop him from spending big bucks to decorate his new mansion. Eric is stressed out by all of the spending and pushes Ari to seal the deal. Meanwhile Drama is fixated on getting calf implants at the cost of $10K.

Mr. Big phones Carrie and invites her to lunch, which she accepts against Miranda's advice. Samantha's sleep is being disturbed by the noise made by some transsexual prostitutes, and she ends up inviting them in for a rooftop party with the other three friends. Charlotte receives an early-morning visit from Trey, who's finally ready for her. Miranda is feeling that her life is in a rut, and runs into Steve on a couple of occasions.

Homer and Marge enjoy a night out on the town. Meanwhile, at home, the kids deal with a diabolical babysitter.

Cigarette Smoking Man returns as Mulder investigates the attempted assassination of a young boy with psychic powers who may be the proof that he has looked for all his life. On his way he encounters many enemies especially in the finale' as his office and every X-File is torched by CSM.