Cigarette Smoking Man returns as Mulder investigates the attempted assassination of a young boy with psychic powers who may be the proof that he has looked for all his life. On his way he encounters many enemies especially in the finale' as his office and every X-File is torched by CSM.

Nancy gets a reality check about what a life of crime can entail. Andy acts like a fool and gets arrested. Celia tries alternative methods to deal with her breast cancer. She also steps out of her box and bonds with children. Shane gets in trouble at school. Again.

Will is stunned to discover that Grace is dating her ex-fiancé Danny once again, but he chooses not to interfere after he's accused of being meddlesome. Meanwhile, Jack agrees to take a walk down the aisle with Karen's combative maid, Rosario, who needs a groom to help her smooth out some immigration problems.

After Will and Grace decide to have a baby together, obstacles pile up before them, including a missing specimen sample and bungled insemination efforts that have them teetering between artificial and natural means – all leading to mis-conceptions. Meanwhile, when Jack considers giving up his show-business aspirations, until he gets some career advice from a "divine" entity – his idol, Cher. Likewise, married Karen is sorely tempted by the romantic tickling of a rich and natty gentleman.

Dan must face the harsh consequences of his decision to murder Keith as Karen and Haley's pregnancies complicate the lives of Nathan and the graduating seniors of Tree Hill High. Lucas wrestles with his post-high school options, and Peyton and Brooke prepare to spend the summer in Los Angeles together.

Naruto has finally caught up with Sasuke, but Sasuke refuses to go back. No matter how much Naruto tries to persuade him, Sasuke refuses. Sasuke decides to leave, and Naruto realizes the only way to stop him is by force.