After Flack makes an enormous drug bust, and locks it up at CSI, the drug lords infiltrate the building at gunpoint to get them back. Now the team must resolve the hostage situations, all the while with Mac, Stella, and Hawkes trapped inside.

Clark discovers the reason Lana married Lex then and sets out to kill Lionel. Lex tries to use DNA from the last phantom to power his super-soldiers. Lois goes to a dam to search for Lex's lab but is caught by a security guard and fatally injured. Chloe's power is discovered.

The squad is left at ends when Lake is caught in a gunfight and later takes a witness hostage.

Stan becomes coach of a Pee Wee Hockey team and for the benefit of one his players he tries to make them into a team of winners. Meanwhile his father deals with the memory of Stan’s performance in a Pee Wee hockey game from years earlier, when Stan had the opportunity to score the game winning goal.

Bette seeks Tina's advice on how to get Jodi back, but is surprised to learn that Tina no longer wants to be straight. Alice is devastated when Tasha is called in for another tour in Iraq. Meanwhile, Phyllis seeks divorce, Jenny is excluded in any decisions regarding the movie, and Helena frees herself from Catherine's tangles.

Tragedy strikes the McNamara/Troy family after Julia learns what has caused her ill health. A visitor from Christian's past brings revealing news. Sean finds the price of fame to be more expensive than it's worth.