Dexter follows clues left for him by the Ice-Truck Killer in an attempt to find the hostage. Paul tries to convince Rita that she and the children are not safe around Dexter.

Buffy arrives too late to save Kendra from Drusilla’s surprise attack, and ends up being arrested for Kendra’s murder. Escaping from the police, she goes to the hospital to find that Willow is comatose and unable to complete the spell to restore Angel’s soul. She also learns that Drusilla took Giles, and heads out to rescue him and stop Angelus once and for all with the help of a most unlikely ally.

Callie and George make a big decision. A successor to Chief Webber is named. A man named Jeff Pope arrives. He is looking for his wife and newborn child. Cristina and Burke's wedding day has arrived and so have the interns exam results.

Shawn investigates the disappearance of a mummy from the National History Museum.

Adam reveals that Riley has a behavior modification chip located just over his heart and wired into his central nervous system. Buffy realizes what Spike is doing and tries to pull the gang back together in time for a final showdown with Adam inside the Initiative itself.