Lynette and Tom uncover the unsettling truth about son Porter. Gabrielle suspects Carlos' best client, Virginia (guest star Frances Conroy), has ulterior motives. Bree's moment of weakness could bring her great embarrassment and shame. Katherine's not-so-little secret is unveiled. Susan learns of Jackson's true passion. Finally, Mrs. McCluskey's sister Roberta (guest star Lily Tomlin) unearths a disturbing fact about Dave.

Nathan learns of his father's plans, while Flint and Knox launch attacks on Hiro, Ando, Peter, and Claire. Meanwhile, Matt tries to revive Angela, Sylar meets with Elle, and Mohinder begins testing of his newest superpower formula.

It's Thanksgiving time and Blair is offended when her Mom's new man hijacks her Thanksgiving traditions. Lily attempts to fix Jenny and Rufus's frail bond. Eric discovers a secret on Bart.

Brainiac strikes and replaces Chloe's memories with Kryptonian code. In order to help his best friend, Clark must ask for Jor-El's help. Meanwhile, Davis tries to get Chloe to understand that Jimmy is wrong for her.

One of Meredith's oldest friends, Sadie, becomes an intern at Seattle Grace, but Mer's friends are less than welcoming to her. Lexie leads her fellow interns in secretive, unorthodox surgical training sessions; and a new surgeon, Harriet Dixon, brings rules and order to the OR.

Turtle scores a first class seat next to the star of a now finished HBO series, and makes a mile-high claim to the guys; Josh Weinstein courts Vince whilst Ari is distracted.