After Steve shows a lack of interest in Stan's job, Stan replaces him with Barry, Steve's malicious friend. Barry frames Steve to eliminate him from the household, but when Steve discovers Barry's weakness, he relies on his CIA skills to save the family. Meanwhile, Roger takes an impressive keg-stand and uses it to become a fraternity brother.
Giles is able to bind Willow, but not for long. Soon her rampage begins again, but an influx of true magick makes her see the world in a new light. Now she can feel the pain of every being on the planet, and she decides that their pain must end. Even if she must destroy the world to do it.
Professor Fine has unleashed a virus that will kill millions. Clark must put a stop to him, while Lex wonders what will happen when he tells Lana his latest secret.
Chuck learns the most shocking secret of her life and refuses to forgive Ned. In order to take the Pie Maker's mind off of Chuck, Emerson gets him to solve the mystery of a man killing life insurance agents and hiding them in snow banks. Oscar Vibenius returns to investigate why Chuck has a unique smell. Meanwhile, the Aunts' antidepressant-laced pies begin to show some hallucinogenic effects.
Jack's decision to put a plan in action in order to set things right on the island is met with some strong resistance by those close to him, and Locke assigns Ben a difficult task.
The First Annual Elmo Talent Show begins as Marin receives a large check for her latest book. Sam's frugality annoys Jane when he decides to drive to Elmo from New York in an RV and Patrick redoubles his efforts to win back Annie.
