Sam, Dean, and Bobby hunt down Lilith and fight her and her demons in a final effort to save Dean's life.

The town of Milan, Ohio, is plagued by a series of calls where the victims are contacted by dead loved ones, and urged to commit suicide. When Dean and Sam investigate, Dean gets a call of his own and the two brothers are soon at odds.

Whilst investigating the haunted Morton Mansion, Sam and Dean run into a couple of familiar faces and become inadvertent participants in a new reality show named Ghostfacers. As events turn deadly and the team are trapped in the house, the investigation becomes a battle to survive until morning.

Dean interrogates a college student after the death of Dr. Greggs. Bobby, Sam and Dean all discover the truth behind the fatal death when they all get locked in a nightmare of their own.

The seemingly harmless practices of a group of neighborhood witches goes bad when one of them kills a woman. Ruby offers her assistance... but she has a few secrets of her own.

FBI Agent Henricksen finally captures Sam and Dean, but is caught in the middle when a horde of demons descends on the small-town jail to eliminate the brothers.

Dean is killed after looking into a case about the disappearance of a man with Sam. The next morning, Sam is shocked to find Dean alive and is hit with the realization that he is reliving the day before.

In this Christmas-themed episode, Sam and Dean follow the trail of an "anti-Santa" that abducts its victims by using their chimneys. Dean tries to get Sam to celebrate Christmas like they used to but Sam doesn't want to accept that it could be the last one they'll spend together.

The brothers capture a female vampire named Lucy who has no idea how she became one, which leads them to Dixon, a male vampire who is a little too giving. Gordon returns with a vengeance leaving Sam in danger.