When Meg boasts that John is her prisoner, the boys visit a friend of their father's to get information about demonic possessions and ways to trap a demon. It turns out Meg is not what she appears.

John has realized where the demon will strike next and the Winchesters head there to stop the next killing. But Meg begins killing John's friends and demands the Colt or she'll keep going until everyone John knows is dead.

To obtain a mystic gun capable of destroying the demon that killed their mother, Sam and Dean must team up with their father John and face off against vampires.

The Winchesters must deal with a dangerous spirit bound to an old family portrait that brings misfortune and death to anyone who buys it.

Sam and Dean battle a Shtriga, a witch that sneaks into childrens' bedrooms and sucks the lives out of them. Dean must relive his childhood when he remembers that he encountered the Shtriga years ago.

Sam and Dean investigate the case of a maniacal ghost inhabiting a long abandoned Texas farmhouse known as "Hell House." They believe the ghost is the spirit of a deceased Depression-era farmer who killed his family, but they soon realize it is something far more powerful.

Sam has a reunion with a girl he once met, Meg, but it turns out that she is using the brothers to lure their father John to his doom.

Dean searches for Sam when he is kidnapped by a backwoods family who likes to hunt humans and use their body parts as trophies.

Sam's precognitive dream leads the brothers to investigate a mysterious death which seems connected to a boy with the power of telekinesis.

Sam and Dean head to Missouri to investigate mysterious car accidents involving black men.