The BAU faces one of its toughest cases when the team is called to New York City to determine if a series of random shootings is the work of one serial killer or a team of killers working together.

After a suspected serial killer wakes up from a coma, the BAU reopens the case and uses brain fingerprinting to determine if he really doesn't remember the crimes that had been committed four years earlier in Roanoke, Virginia.

The team members try to identify a stalker before he can attack a woman who is being stalked in Silver Spring, Maryland. Meanwhile, Hotch and Rossi are called as consultants on a possible battered woman syndrome murder case in Boston.

The BAU is called to Miami to investigate a serial killer who appears to have a conflicted sexual identity. Meanwhile, JJ's secret is revealed.

The BAU is called to West Bune, a small town in Texas, to investigate what appears to be spree killings that involve a teenaged boy and his girlfriend.

The BAU is called to Pittsburgh after an unusually high suicide rate appears to be the work of an Angel of Death.

Rossi goes to Indianapolis to continue his investigation into the two unsolved murders that have plagued him for 20 years, and he is joined by Prentiss, JJ, and Morgan when they learn about the case. Meanwhile, Hotchner and Reid interview a death-row inmate in a Connecticut prison.

After the contents of a self-storage unit purchased at an auction take the BAU to Philadelphia to investigate a series of murders, the local agent becomes the center of the case. To catch the killer, the team must profile the items inside the unit.

When one teenager is found murdered and her best friend is abducted in Chula Vista, California, the BAU must profile the killer and find him before he kills the other teen.

The new sheriff in Fredericksburg, Virginia, requests the BAU's assistance in the investigation of a series of mutilation murders that appear to mimic similar crimes that had occurred over two decades earlier.