Sam and Dean come across a series of comics called Supernatural depicting their lives as demon hunters in detail. The brothers meet the author of the comics, Carver Edlund, who explains he has visions of Sam and Dean in action then puts their adventures in the comics.
As the Apocalypse approaches, Castiel and Zachariah inform Dean that his moment of glory draws nigh. Sam, disagreeing, goes with Ruby to take on Lilith.
Sam is locked in Bobby’s panic room to cleanse his body from demon blood. However, after several seals are broken Bobby wants to set Sam free to help stop the Apocalypse and Dean seeks out Castiel for help.
Dean has a dream about Castiel asking to meet him in private. Sam and Dean are shocked to discover Castiel’s human host, Jimmy, is back in control. Jimmy wants his life back but Sam and Dean believe he is in danger.
Sam and Dean are on a hunting trip when they come across a guy named Adam Milligan. Later they find out Adam was conceived when his mother fell in love with a hunter who just so happens to have been John Winchester.
Sam and Dean come across a series of comics called Supernatural depicting their lives as demon hunters in detail. The brothers meet the author of the comics, Carver Edlund, who explains he has visions of Sam and Dean in action then puts their adventures in the comics.
Sam and Dean live normal, separate lives but they don’t seem to know each other, even though they work at the same company. However, when colleagues start committing suicide, they team up to investigate the situation.
Angels get slaughtered by Lucifer’s sword. Castiel and Uriel hold Alastair captive and ask Dean to use his newfound techniques in torture to take valuable information that can put an end to the murders. Dean learns some shocking facts from Alastair.
Sam and Dean seek help from Pamela, who sends the brothers to the spiritual realm. They discover Alastair attempting to break the seal causing mayhem in the mortal world by stopping death from occurring in a small town.
A siren casts a spell on Sam and Dean while they are on a mission in Iowa leading to their violent behavior.
Sam and Dean investigate a haunting at one of the high schools they attended as teenagers.
Sam and Dean are faced with magicians delving in black magic. They investigate after several people wind up dead in ways similar to the illusions the magicians perform on stage.
Sam and Dean investigate a house occupied by a female ghost, but when a new family moves in things take a turn for the worse.
Sam, Dean, and Ruby look for Anna who hears the voices of angels. When Ruby seemingly betrays the brothers and leaves with Anna, Sam enlightens Dean on how Ruby saved Sam’s life while Dean was in Hell.
Dean and Sam figure out why Castiel and Uriel want Anna dead. Alastair and his minions try to track down Sam, Dean and Anna.
The Winchesters investigate a town wishing well that really grants wishes… at a terrible cost.
Sam and Dean meet Castiel and his fellow angel Uriel, who warn the brothers to avoid intervening in a town plagued by demons.
Posing as federal marshalls for not-the-first time, Sam and Dean begin investigating a ghost sickness that instills fear in its victims. Things get a little harder when Dean himself gets infected by the heebie-jeebies and starts to scare himself to death - literally.
Sam and Dean face off against a shapeshifter with a serious liking for classic black-and-white horror movies.
Sam and Dean find Jack who is changing into a rugaru, a flesh-eating demon that preys on humans. Sam and Dean have a disagreement on how to deal with Jack.
Dean gets transported back in time and ends up in Lawrence, Kansas, where he crosses paths with a young version of his parents, who have just fallen in love.
Ghosts of children Bobby couldn’t save cripple him with guilt and Sam and Dean must save him. However, they must also ignore the spirits of Meg and Agent Hendricksen, who have come back to accuse the brothers of failing them.
Bobby, Sam, and Dean visit an old friend of Bobby’s, a psychic, to help them get some answers as to how and why Dean has returned from Hell.
Summary: Locke tasks Sawyer with a mission, and Kate talks to Locke while holding a fake, plastic gun while Sayid is watching them.
Summary: Members of the sales staff let Sabre’s new Sales Is King policy go to their heads.
Summary: A high school senior repeatedly hallucinates after blacking out during a class trip; Wilson tries to furnish his condo.
Summary: The team reopens the case of a dock worker, who moonlighted as a professional wrestler, who was shot dead in 1986; Valens secretly looks into a lead on the man who mugged and raped his mother.
Summary: Casey carries out a side mission for his old commanding officer James Keller that leads to him committing treason. When Chuck learns the dark truth about Col. Keller, he and Sarah set out to break Casey out of jail and clear his name. Meanwhile, Awesome’s plan to keep Ellie out of danger gets more difficult when she gets her dream fellowship.
Summary: Kitty’s popularity surge creates havoc for her family; Luc faces the possibility of deportation; Nora reaches out to Tommy for help.
Summary: Naomi goes on her first hike with Ivy and Liam; Annie gives Jasper an ultimatum; Gia and Adrianna’s friendship grows.
Summary: Liz keeps running into Wesley (Michael Sheen), causing her to question their decision; Jack tries to secure his position in the new company.
Summary: While Jack and Cole team up in the field to shield New York from the calamitous threat, a hostage situation has CTU completely stressed out. Meanwhile, unrelenting parole officer Prady presses on in his investigation, and unexpected developments send the Hassan family into a major tailspin.
Summary: Rufus and Lily grow suspect of Jenny’s relationship with Damien. Chuck learns more about the woman who may or may not be his mother. Dan and Vanessa struggle through the awkwardness of dating other people.